Study record managers: refer to the Data Element Definitions if submitting registration or results information. Aortic Stenosis is a common but fatal disease when it becomes symptomatic, specially if not treated.
Until now surgery remains the only reliable and effective treatment. The investigators hypothesize that MK-7 supplementation may slow or even reverse the progression of the disease process. The study is a randomized clinical trial that will use Cardiac Echography and multi-detector computed tomography to compare the changes in the Aortic Valve Calcification Score AVCS over 3 years when using:.
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Surgeon Q&A: What Are 8 Important Facts About Calcified Heart Valves?
Eligibility Criteria.By Adam Pick on September 15, Your valve is stenotic. You need a new valve. Do I really need heart surgery?
That said, I receive a lot of excellent questions from our community about heart valve calcification. So, I wanted to create a special post dedicated to this very important topic. To get the latest research about heart valve calcification, I contacted two cardiac surgeons that specialize in heart valve therapy — Dr.
Heart valves are normally formed of leaflets that are thin and pliable. The stenotic heart valve in turn leads to increased resistance to blood flow and increased cardiac work. One particular reason is attributed to the normal wear and tear of the heart valves because of the fact that the heart is the hardest working muscle in the body.
In addition, there can be genetic reasons which include congenital valve abnormalities where the valve stiffens later in life. Other factors that contribute to calcification include smoking, diabetes, chronic kidney disease and elevated cholesterol and triglyceride levels. Most valves become calcified by atherosclerosis, which is a process that causes blockages in the arteries of the heart as well as the rest of the body. Calcified Aortic Valve. An inflammation can occur on the heart valve that leads to a reaction in the blood stream which promotes calcification.
Despite all these potential reasons, the exact mechanism causing heart valve calcification is still being investigated. Other causes of aortic valve calcification or valve stiffening include radiation exposure to the chest and rheumatic aortic valve disease.
It is very unusual for the right- sided heart valves tricuspid and pulmonary to calcify and it is not really clear why. When the aortic valve calcifies, it affects both, the valve leaflets doors and the annulus the ring on which the valve sits. When the mitral valve calcifies, it mainly affects the annulus ring but can also involve the leaflets.
New paper: Vitamin K2 recommended to support heart health in aortic valve calcification
The most common disease that causes mitral valve calcification is rheumatic valve disease. This typically occurs when a streptococcal throat infection affects the valve during youth but will not become evident until adolescence or adulthood. Bicuspid aortic valves BAV and other valve anomalies result in particularly turbulent blood flow, which is why these patients present with valve calcification at a much earlier age. Lightheadedness and chest pain are other common symptoms.
Contrary to the skeletal muscle in the rest of our body, heart muscle enlargement or thickening will negatively affect the heart. The likelihood of this occurring, however, is very low in patients who have not yet developed symptoms. Such symptoms are usually quick to resolve after valve replacement surgery. There are 2 broad categories of replacement valves — mechanical and bio-prosthetic. Mechanical heart valve replacements are usually made of a metal material.
Bio-prosthetic heart valve replacements are made of animal tissue, either cow or pig. Mechanical left and Bio-Prosthetic right Heart Valves.
The heart valves can be replaced with a surgical approach which can be performed in the conventional manner by opening the sternum breast bone or by a minimally invasive approach through a small incision on the side of the chest. In both of these procedures, the heart chamber is opened and the diseased valve is completely removed and a new valve is implanted.
Another option now available in selected patients with aortic valve stenosis is a trans-catheter aortic valve replacement TAVR. The diseased valve is not removed and the patient does not need to be placed on the heart lung machine. Transcatheter Aortic Valve Replacement. Bio-prosthetic valves that are implanted in young patients as well as those on dialysis have a greater chance of calcifying earlier.
The natural stress on the valve from wear and tear can also lead to calcification and degeneration of the artificial valve.Conflicting calcium information. That in conjunction with doctors now testing for arterial calcification, has led to some confusion that calcium supplementation is bad for you. Adequate intake of vitamin K2 has been shown to lower the risk of vascular damage because it activates MGP, which inhibits calcium from depositing in the vessel walls.
Hence, calcium is available for other multiple roles in the body, leaving the arteries healthy and flexible. However, vitamin K deficiency results in inadequate activation of MGP, which greatly impairs the calcium removal process and increases the risk of blood vessel calcification.
Vitamin K2 is essential for bone and cardiovascular health: without vitamin K2, calcium is not properly directed to bones, allowing it to build up in blood vessel walls and soft tissues. The population-based Rotterdam study evaluated healthy men and women aged 55 and older, and the relationship between dietary intake of vitamin K and aortic calcification, heart disease and all-cause mortality. These findings were supported by another population-based study with 16, healthy women aged 49—70 from the Prospect-EPIC cohort population.
A recent study published in the Journal Thrombosis and Haemostasis, has helped to confirm the link between Vitamin K intake and heart health. This 3 year study on postmenopausal women, found that taking mcg of MK-7 version of Vitamin K2 daily reduced stiffness in the arteries and improved elasticity in the blood vessels. Lead researcher Cees Vermeer and his colleagues studied postmenopausal women. Half were given Mk-7 and the other half were given a placebo.
They used ultrasound technology to evaluate thickness and stiffness. Women who had the highest stiffness measures in the beginning were seen to have improved carotid artery elasticity as the study progressed.
As we age, our arteries begin to stiffen due to calcification. Vitamin K2 helps protect against soft tissue calcification. This study is one of the first to show a reversal of arterial stiffness using this long acting form of Vitamin K2.
An abundance of human clinical data reveals that vitamin K found in Super K plays a critical role in maintaining healthy bone density by facilitating the transport of calcium from the bloodstream into the bone. Vitamin K is also required by calcium-regulating proteins in the arteries. Matrix Gla-protein MGP is a vitamin K-dependent protein, and it must be carboxylated to function properly. Since MGP is a potent local inhibitor of arterial calcification, MGP is important in relation to the health of the entire cardiovascular system.
Without adequate vitamin K, calcium in the blood can bind to the arterial wall resulting in calcification.
Poor vitamin K status also results in increased circulating levels of undercarboxylated osteocalcin that is shown to be associated with increased bone loss in postmenopausal women. Humans get most of their vitamin K from green vegetables in the form of vitamin K1.Cardiovascular disease CVD is the number one global cause of death. CVD is influenced by genetics, but behavioural and lifestyle factors also play a role.
Heart disease and stroke risk can be mitigated through a healthy diet, regular physical activity and the avoidance of risk factors such as smoking. An estimated Of these, an estimated 7.What is Vitamin K2?
Although heart disease represents individual and family hardship, in broader terms, CVD is estimated to cost the EU h billion annually. Calcium is an essential nutrient. Vital for bone health, calcium is also important for muscle contraction, proper nerve signalling and a range of other metabolic functions.
Vitamin D3 is a helper to calcium, assisting calcium absorption through the intestine and into the bloodstream where it can be put to productive use.
Bone building represents most calcium use in the body; specialised enzymes bind calcium in the blood, transport it to our bones and integrate it into the bone matrix.
What about when the body gets too much calcium, or the calcium that is present is not fully or correctly utilised by the body? What happens when calcium becomes out of balance? Too much calcium, whether derived from diet or supplementation, is unhealthy. The soft tissues of the body, specifically the arteries and vessels of the circulatory system, can begin to absorb and integrate excess calcium in a process called tissue calcification.
Skin callouses and kidney stones are other examples of tissue calcification and the improper use of calcium. As a mineral, calcium provides strength and structure to bones, buildings and ocean reefs. In the case of calcified arteries and vessels arteriosclerosisstiffening decreases their ability to expand outward to deliver increased blood flow and oxygen when the body needs it during physical activity.
The heart must work harder to pump higher volumes of blood through a ridged, less flexible circulatory system. Arteries and vessels also harden and lose flexibility as a result of calcium build-up within the walls of the vessels atherosclerosis.
This typically takes the form of a plaque consisting of calcium and lipids deposited within the vessel walls. These build-ups of calcified plaques further reduce vessel elasticity and compound the stresses on the heart. Plaque build-up reduces the diameter of vessels, making the heart work even harder to push blood through smaller vessels.Vitamin K2 is the only known substance that can stop and reverse soft tissue calcification.
Soft tissue calcification is one of the most serious health problems we face as individuals, as modern societies, and, on a global scale, as a species. Arthritis, of which basically everyone past the age of 40 suffers, and increasingly more with time and with age, is a disease of soft tissue calcification. Soft tissue calcification also causes kidney stones and kidney disease. Hardly any. And how many young men and women in their 20s and 30s already have kidney stones and kidney dysfunction?
More and more every year.
It is really remarkable. And so, maybe you are wondering why it is such a major and widespread problem, why it affects everyone no matter where we are or what we do. Naturally, the next question is why? Why is our intake of vitamin K2 so inadequate? If it is such a crucial essential nutrient, we would surely not be here as a species if intake had always been so inadequate. Looking at things the other way around, if we are so dependent on adequate K2 intake for staying healthy, this must necessarily mean that we evolved having plenty of it in our food supply.
The short answer is that K2 is found in the fat of pastured animals that graze on fresh green grass, and produced from vitamin K1 by certain kinds of bacteria in their gut. The longer answer is that vitamin K2 is a family of compounds called menaquinones, ranging from MK-4 to MK depending on their molecular structure.
These compounds are derived from the plant analog, the sister compound, vitamin K1, called phylloquinone, and found in chlorophyll-rich plant foods. The resulting menaquinone is then stored in the fat cells of the animal as well as in the fat of their milk if they are milk-producing.
Consuming these animal fats in which vitamin K2 has been concentrated will provide this precious essential micronutrient. If the grazing animal does not feed on green grass, they get no vitamin K1.
If they get no vitamin K1, their gut flora is not only compromised and negatively altered with respect to what it should be if they were consuming the grass they have evolved eating, but it produces no vitamin K2. If their gut flora produces no vitamin K2, their fat and milk will contain no vitamin K2, and neither their offspring nor any person consuming products derived from the animal will get any vitamin K2. It is most natural that grass-eating animals should be grazing on fresh green grass in open pastures.
And yet, it is rather rare. But without green grass, there is no vitamin K1.By Adam Pick on August 10, I am sending you an article about Vitamin K2 and how it is preventing calcification of arteries, heart valve stenosis and osteoporosis. I have been taking Vitamin K2 since last September and I am feeling much better. I feel that other people should read about Vitamin K2 and its potential benefits for heart disease patients.
I reviewed the article and became intrigued by Vitamin K2 given its potential value for blocked arteries and calcified heart valves. So you know, I began using supplements and fish oil after my heart valve surgery to help with ongoing fatigue.
Given Dr. This is not evidence-based. We all ingest Vitamin K — it is found in leafy, green vegetables. There is no conclusive or even good evidence that supplements of Vitamin K have any health benefit.
They may be particularly dangerous for those on Coumadin Warfarin. Similar to most discussions about nutritional supplements, there is always room to debate the safety, efficacy and actual benefits of these products. However, I wanted to address this topic so that we could all learn from Alicja and Dr.
I hope this helped you learn more about Vitamin K2 and its potential uses for heart health including calcified heart valves and blocked arteries. InAdam founded HeartValveSurgery. This award-winning website has helped over 10 million people fight heart valve disease. Starnes on April 19, I am now Well, as Doc G, did my surgery, I guess I should listen to him, but the K2 does sound interesting as a supplement. Can it hurt if you have a repair and not on a bloodthinner?
Of special note. One thing pts on warfarin are not told is warfarin causes hardening of the arteries. It does and we know it does. K2 prevents that hardening and will reverse it. Evidence based medicine could be said another way.
What are drug companies willing to study? They are not willing to study things like K2 as it is already readily available, no money to be made. Further, when using nutraceuticals were are just using identified food parts to obtain better health.
I have been reading loads of research on the web about vitamin k2 and how important it is for making sure calcium is deposited in the bones and not in tissue and arteries.
Interestingly one article placed people taking warfarin as in the same category as those with vitamin K deficiency …. I have been taking a vitamin K2 supplement of mcg for a couple of weeks now and my INR has dropped alot although it was dropping before that. I do feel a bit depressed about the whole thing.
I know taking warfarin is ruining my bones and potentially calcifying my arteries and heart valve. Without it I can get a stroke and die.This site is operated by a business or businesses owned by Informa PLC and all copyright resides with them.
Vitamin K2 recommended to support heart health in aortic valve calcification: new paper
Registered in England and Wales. Number Nov 21, European Heart Journal has published an important review paper that highlights the potential of Vitamin K2 supplementation for calcific aortic valve stenosis CAVSa common cardiovascular condition in the aging population where no medical therapy currently exists.
According to researchers, once symptomatic severe CAVS has developed, the prognosis without intervention is dismal. Currently the only treatment for symptomatic severe CAVS is surgical or trans catheter aortic valve replacement AVRto which not all patients are suited. While multiple trials have attempted to repurpose commonly used pharmacological interventions to slow CAVS progression, pharmacological interventions have thus far failed to alter the course of CAVS.
The review paper notes that studies have demonstrated that statins, widely used for lipid lowering in atherosclerosis and inflammation, have no effect on CAVS progression or clinical outcomes, and might actually exacerbate the condition. However, the researchers noted promise with Vitamin K2, specifically the long-chain menaquinones MK7as they are transported efficiently beyond the liver. Specifically, our three-year cardiovascular study in healthy postmenopausal women taking just mcg daily of Vitamin K2 as MK-7 as MenaQ7which demonstrated a cessation and even regression in arterial stiffness.
With this advancing knowledge, we have identified novel therapeutic targets like vitamin K and new imaging techniques that can be used to test the efficacy of novel agents and further inform our pathophysiological understanding. Knapen MHJ, et al.
Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women: double-blind randomised clinical trial. Thrombosis and Haemostasis 19; 5. Peeters FECM, et al. Calcific aortic valve stenosis: hard disease in the heart.
Decalcification of the Aortic Valve by Vitamin K2 (Menaquinone-7) (DECAV-K2)
Euro Heart J 0, The company has a multi-year research and development program to substantiate and discover the health benefits of vitamin K2 for applications in the marketplace for functional food and dietary supplements.
New paper: Vitamin K2 recommended to support heart health in aortic valve calcification The European Heart Journal has published an important review paper that highlights the potential of Vitamin K2 supplementation for calcific aortic valve stenosis CAVSa common cardiovascular condition in the aging population where no medical therapy currently exists.
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